There has been a discussion about the dating of the folio numbering of the Voynich manuscript over the years. Some experts suggest the page numbers could have been placed on the parchment as late as 16th and 17th century.
It is clear that the folio numbers of the VMs do not belong in the early 15th century because numbers 4 and 7 were written differently at that time.
Is it possible though for the page numbers to originate in the 15th century. It seems the answer is: Yes, in the late 15th century.
Below is a comparison of the VMs folio numbers with the fonts used in the Treviso Arithmetic - the first printed math book in the West that came off the presses in 1478.